Andrew McCaddon is a Full Time Principal General Practitioner in Gardden Road Surgery, Rhosllanerchrugog Wrexham. His work in relation to the discovery of a mutation in the Amyloid Precursor Protein gene in the early 1990s led to his key clinical observation of low levels of vitamin B12 and folate in these patients. In 1992 he described how such deficiencies contribute to impaired cognition, and predicted that Alzheimer patients would have elevated blood levels of homocysteine. This was confirmed by his research team in 1998. Elevated blood levels of homocysteine are now a recognised risk factor for cognitive decline and incident dementia.

Dr McCaddon is also an Honorary Senior Research Fellow in the School of Medicine, Cardiff University. His MD with Distinction was awarded by Sheffield University for his thesis 'Vitamin B12 deficiency and Alzheimer's disease'. He was also awarded the 2010 William Farr Medal by the Worshipful Society of Apothecaries for his significant contribution to research concerning the care of elderly patients. He is the Founder and Scientific Director of “COBALZ Limited”, a company developing combined B vitamin and antioxidant supplements. COBALZ recently launched Betrinac (www.betrinac.com) - a vitamin supplement containing B12, B6, folic acid and N acetylcysteine. Betrinac can help maintain brain performance and memory as you get older.